Journal
OBESITY
Volume 22, Issue 12, Pages 2563-2569Publisher
WILEY
DOI: 10.1002/oby.20900
Keywords
-
Categories
Funding
- Intramural Research Program of the NIH, National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Pennington NORC Center Grant [P30 DK072476]
- NIDDK [R01-DK070860, DK20593, DK058404, K01DK89005]
- Vanderbilt CTSA from NCRR [1 UL1 RR024975]
Ask authors/readers for more resources
ObjectiveTo measure changes in resting metabolic rate (RMR) and body composition in obese subjects following massive weight loss achieved via bariatric surgery or calorie restriction plus vigorous exercise. MethodsBody composition and RMR were measured in 13 pairs of obese subjects retrospectively matched for sex, body mass index, weight, and age who underwent either Roux-en-Y gastric bypass surgery (RYGB) or participated in The Biggest Loser weight loss competition (BLC). ResultsBoth groups had similar final weight loss (RYGB: 40.212.7 kg, BLC: 48.8 +/- 14.9 kg; P=0.14); however, RYGB lost a larger proportion of their weight as fat-free mass (FFM) (RYGB: 30 +/- 12%, BLC: 16 +/- 8% [P<0.01]). In both groups, RMR decreased significantly more than expected based on measured body composition changes. The magnitude of this metabolic adaptation was correlated with the degree of energy imbalance (r=0.55, P=0.004) and the decrease in circulating leptin (r=0.47, P=0.02). ConclusionsCalorie restriction along with vigorous exercise in BLC participants resulted in preservation of FFM and greater metabolic adaption compared to RYGB subjects despite comparable weight loss. Metabolic adaptation was related to the degree of energy imbalance and the changes in circulating leptin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available