Journal
OBESITY
Volume 23, Issue 2, Pages 329-334Publisher
WILEY-BLACKWELL
DOI: 10.1002/oby.20923
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Funding
- National Institutes of Health [DK037948, DK097608, DK056341, UL1 RR024992]
- Longer Life Foundation
- National Natural Science Foundation of China [31371437]
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ObjectivesAn increase in circulating branched-chain amino acids (BCAA) is associated with insulin resistance. Adipose tissue is a potentially important site for BCAA metabolism. It was evaluated whether monomethyl branched-chain fatty acids (mmBCFA) in adipose tissue, which are likely derived from BCAA catabolism, are associated with insulin sensitivity. MethodsInsulin-stimulated glucose disposal was determined by using the hyperinsulinemic-euglycemic clamp procedure with stable isotope glucose tracer infusion in nine lean and nine obese subjects, and in a separate group of nine obese subjects before and 1 year after Roux-en-Y gastric bypass (RYGB) surgery (38% weight loss). Adipose tissue mmBCFA content was measured in tissue biopsies taken in the basal state. ResultsTotal adipose tissue mmBCFA content was approximate to 30% lower in obese than lean subjects (P=0.02) and increased by approximate to 65% after weight loss in the RYGB group (P=0.01). Adipose tissue mmBCFA content correlated positively with skeletal muscle insulin sensitivity (R-2=35%, P=0.01, n=18). ConclusionsThese results demonstrate a novel association between adipose tissue mmBCFA content and obesity-related insulin resistance. Additional studies are needed to determine whether the association between adipose tissue mmBCFA and muscle insulin sensitivity is causal or a simple association.
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