Journal
OBESITY
Volume 22, Issue 2, Pages 608-615Publisher
WILEY-BLACKWELL
DOI: 10.1002/oby.20565
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Funding
- NIH [R01 DK06800107]
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Objective: To explore the long-term impact of intrauterine growth restriction (IUGR) among a diverse, contemporary cohort of US children. Design and Methods: A retrospective cohort of 42 children exposed to IUGR and 464 unexposed who were members of Kaiser Permanente of Colorado. Height and weight measurements since birth and measures of abdominal adiposity and insulin-resistance were measured at an average age of 10.6 (61.3) years. Results: Infants born IUGR experienced catch-up growth in the first 12 months of life at a rate of 3.58 kg/m(2) compared to 2.36 kg/m(2) in unexposed infants (P = 0.01). However, after 1 year of age, no differences in BMI growth velocity were observed. Nevertheless children exposed to IUGR had higher waist circumference (67.0 vs. 65.3 cm, P = 0.03), higher insulin (15.2 vs. 11.0 mu U/ml, P = 0.0002), higher HOMA-IR (2.8 vs. 2.3, P = 0.03), and lower adiponectin levels (9.0 vs. 12.0 mu g/ml, P = 0.003) in adolescence, independent of other childhood and maternal factors. Conclusions: Our data from a contemporary US cohort suggests that children exposed to IUGR have increased abdominal fat and increased insulin resistance biomarkers despite no differences in BMI growth patterns beyond 12 months of age. These data provide further support for the fetal programming hypothesis.
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