Journal
OBESITY
Volume 21, Issue 10, Pages 2037-2045Publisher
WILEY-BLACKWELL
DOI: 10.1002/oby.20354
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Funding
- Netherlands Organization for Scientific Research (NWO Zon-MW) [917.76.301]
- Netherlands Consortium for Systems Biology (NCSB)
- Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/NWO)
- Dutch Diabetes Research Foundation [2005.01.003]
- EU [202272]
- PREDICCt [01C-104]
- Netherlands Heart Foundation
- Dutch Diabetes Research Foundation
- Dutch Kidney Foundation
- Netherlands Heart Foundation [2009T038]
- Medical Research Council [G0600717, MC_UU_12012/5/B, MC_UU_12012/5, G0600717B] Funding Source: researchfish
- MRC [G0600717, MC_UU_12012/5] Funding Source: UKRI
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Objective: The scavenger receptor CD36 facilitates the cellular uptake of long-chain fatty acids. As CD36-deficiency attenuates the development of high fat diet (HFD)-induced obesity, the role of CD36deficiency in preadipocyte recruitment and adipocyte function was set out to characterize. Design and Methods: Fat cell size and number were determined in gonadal, visceral, and subcutaneous adipose tissue of CD36(-/-) and WT mice after 6 weeks on HFD. Basal lipolysis and insulin-inhibited lipolysis were investigated in gonadal adipose tissue. Results: CD36(-/-) mice showed a reduction in adipocyte size in all fat pads. Gonadal adipose tissue also showed a lower total number of adipocytes because of a lower number of very small adipocytes (diameter < 50 mu m). This was accompanied by an increased pool of preadipocytes, which suggests that CD36-deficiency reduces the capacity of preadipocytes to become adipocytes. Regarding lipolysis, in adipose tissue from CD36(-/-) mice, cAMP levels were increased and both basal and 8-bromo-cAMP stimulated lipolysis were higher. However, insulin-mediated inhibition of lipolysis was more potent in CD36(-/-) mice. Conclusions: These results indicate that during fat depot expansion, CD36-deficiency negatively affects preadipocyte recruitment and that in mature adipocytes, CD36-deficiency is associated with increased basal lipolysis and insulin responsiveness.
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