Journal
OBESITY
Volume 19, Issue 9, Pages 1908-1911Publisher
WILEY
DOI: 10.1038/oby.2011.195
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Funding
- CNPq-Brazilian National Research Council (Brasilia, Brazil)
- CAPES/Ministerio da Educacao (Brasilia, Brazil)
- FAPERJ-Research support foundation of Rio de Janeiro (Rio de Janeiro, Brazil)
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Our purpose was to investigate the prognostic impact of overweight/obesity in 5-year event-free survival (EFS) in a cohort of children with acute lymphoblastic leukemia (ALL). We retrospectively analyzed 181 newly diagnosed ALL children enrolled between 1990 and 2009 and treated with Berlin-Frankfurt-Munich (BFM) protocols. The majority of children in our cohort were <10 years-old. Our data clearly indicated that overweight/obesity is an independent predictor of relapse risk, mainly in the intermediate-and high-risk groups (HR) of children. These results could be explained by changes in the chemotherapy pharmacokinetics in overweight/obese patients and by the antiapoptotic effects in leukemic cells caused by adipocytes.
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