The fluorescence detection of glutathione by •OH radicals' elimination with catalyst of MoS2/rGO under full spectrum visible light irradiation

In this study, a new method for the detection of glutathione (GSH) was designed based on the center dot OH radicals' elimination system due to the reducing ability of GSH for the first time. Fluorescence method with terephthalic acid (TA) as the probe was employed for the quantification of center dot OH radicals' production and elimination. Experimental conditions of center dot OH radicals' production were optimized in detail, and center dot OH radicals were found to be efficiently produced by the excellent catalysis performance of MoS2/rGO under full spectrum visible light irradiation. The introduction of GSH make fluorescent intensity decrease due to the elimination of center dot OH radicals. For the present fluorescence based GSH sensor, a wide detection range of 60.0-700.0 mu M and excellent selectivity have been achieved. Furthermore, it has been successfully employed for the determination of GSH in commercial drug tablets and human serum. (C) 2015 Elsevier B.V. All rights reserved.