Journal
OBESITY
Volume 16, Issue 4, Pages 902-904Publisher
WILEY
DOI: 10.1038/oby.2007.126
Keywords
-
Categories
Funding
- NCRR NIH HHS [M01 RR000064] Funding Source: Medline
- NIDDK NIH HHS [R01 DK055006] Funding Source: Medline
Ask authors/readers for more resources
Variants in the FTO gene have been strongly associated with obesity in a very large sample ( 38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene ( rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies. The studies included a random sample of the Utah population, families selected for aggregation of extreme thinness, families selected for severe obesity, a series of unrelated severe obesity subjects, and families participating in a 25-year longitudinal study of cardiovascular disease and aging. Results show a strong significant increase in the rs9939609 A allele frequency with increasing BMI ( P < 0.0001). In the longitudinal study, FTO genotypes were significantly associated with BMI at a baseline exam, a 2 1/2-year follow-up exam and a 25-year follow-up exam using an additive genetic model. The mean genotype difference in BMI ranged from 1.3 to 2.1 kg/m(2) across exams. The genotype difference in BMI means was established in youth, and at-risk subjects under age 20 at baseline had a significantly larger 25-year BMI increase ( 10.0 for A/A; 9.7 for A/T, and 8.5 kg/m(2) for T/T, P = 0.05). We conclude that the BMI increases associated with FTO genotypes begin in youth and are maintained throughout adulthood.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available