Journal
OBESITY
Volume 16, Issue 12, Pages 2682-2689Publisher
WILEY
DOI: 10.1038/oby.2008.413
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Funding
- Swedish Research Council
- Research Council for Social Sciences
- Heart and Chest Fund
- King Gustaf V's and Queen Victoria's Foundation
- Vasterbotten and Norrbotten County Councils
- Swedish Public Health Institute
- Swedish Heart and Lung Foundation
- Swedish Medical Society
- Medical Faculties of Lund and Umea Universities
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Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmo Diet and Cancer Cohort (MDCC) and the Northern Sweden MONICA project. We found a significant or borderline association between obesity parameters and telomere length in women after age and center adjustments (BMI: r = -0.106, P = 0.021, weight: r = -0.087, P = 0.060, waist circumference: r = -0.099, P = 0.032, hip circumference: r = -0.128, P = 0.005). In men, a positive borderline correlation to high-density lipoprotein (HDL) (r = 0.111, P = 0.053) and a negative correlation to 2-h post-oral glucose-tolerance test (OGTT) was observed (r = -0.202, P = 0.045). In neither group any association was found between telomere length and cholesterol, serum triglycerides, serum low-density lipoprotein, plasma insulin, blood pressure, pulse pressure, or smoking habits. Our data indicate that telomere length is associated with an obesity-phenotype but only in women.
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