Journal
NUTRITION REVIEWS
Volume 71, Issue -, Pages S42-S54Publisher
OXFORD UNIV PRESS INC
DOI: 10.1111/nure.12068
Keywords
altricial mammalian species; maternal obesity; offspring phenotype; offspring programming mechanisms; precocial mammalian species
Categories
Funding
- CONACyT (Consejo Nacional de Ciencia y Tecnologia), Mexico [155166]
- Sociedad Mexicana de Nutricion y Endocrinologia
- National Institute of Child Health and Human Development [HD 21350]
Ask authors/readers for more resources
Maternal obesity can profoundly affect offspring phenotype and predisposition to obesity and metabolic disease. Carefully controlled studies in precocial and altricial mammalian species provide insights into the involved mechanisms. These include programming of hypothalamic appetite-regulating centers to increase orexigenic relative to anorexigenic drive; increasing maternal, fetal, and offspring adrenal and peripheral tissue glucocorticoid production; and increasing maternal oxidative stress. Outcomes often show offspring sex differences that may play a role in the differential susceptibility of males and females to later-life obesity and other related metabolic diseases. (C) 2013 International Life Sciences Institute
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available