Journal
NUTRITION REVIEWS
Volume 68, Issue 12, Pages S112-S118Publisher
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2010.00346.x
Keywords
brain; folate; homocysteine; one-carbon metabolism; vitamin B-12
Categories
Funding
- US Department of Agriculture (USDA) [58-1950-7-707, 51520-008-04S]
Ask authors/readers for more resources
Deficiencies of the vitamins folate, B-12, and B-6 are associated with neurological and psychological dysfunction and with congenital defects. In the elderly, cognitive impairment and incident dementia may be related to the high prevalence of inadequate B vitamin status and to elevations of plasma homocysteine. Plausible mechanisms include homocysteine neurotoxicity, vasotoxicity, and impaired S-adenosylmethionine-dependent methylation reactions vital to central nervous system function. In light of this, it is imperative to find safe ways of improving vitamin B status in the elderly without exposing some individuals to undue risk.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available