Journal
NUTRITION REVIEWS
Volume 68, Issue 3, Pages 178-181Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1753-4887.2010.00274.x
Keywords
anticoagulants; diet; phylloquinone; vitamin K; warfarin
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Funding
- U.S. Department of Agriculture, Agricultural Research Service [58-1950-7-707]
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Numerous risk factors for instability of oral anticoagulation have been identified, including variability in vitamin K intake. However, few studies have directly tested the feasibility of manipulating dietary vitamin K to achieve stable oral anticoagulation. Recent findings from a randomized clinical trial suggest that dietary vitamin K manipulation is a viable option for managing stability of oral anticoagulant therapy. The approach appears to be effective for those patients who are under-anticoagulated and consume a small number of vitamin K-rich food sources. While an encouraging option for management of warfarin therapy, longer-term studies in different patient populations are required. (C) 2010 International Life Sciences Institute
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