Journal
NUTRITION REVIEWS
Volume 68, Issue 3, Pages 155-167Publisher
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2010.00272.x
Keywords
docosahexaenoic acid; eicosapentaenoic acid; fish oil; omega-3 fatty acids; triglycerides
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Funding
- Cargill Incorporated
- Denomega Nutritional Oils AS
- EPAX AS
- Monsanto
- Ocean Nutrition Canada
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The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent reductions in fasting serum TG levels at the recommended intakes of 200-500 mg/day. The assessment included 15 randomized controlled trials that met pre-defined inclusion and exclusion criteria. Across these 15 studies, the dose-response was modeled using a first-order elimination curve. The response variable was defined as percent change from baseline in fasting serum TG, adjusted for the placebo effect. A weighting factor equal to the product of each study's sample size and quality score was used. Using the equation of the dose-response curve, predicted reductions in fasting serum TG levels at the recommended long-chain omega-3 fatty acid intakes of 200-500 mg/day are 3.1 to 7.2%. (C) 2010 Cantox Health Sciences Inc. Journal compilation (C) 2010 International Life Sciences Institute
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