Journal
NUTRITION REVIEWS
Volume 67, Issue 11, Pages S152-S163Publisher
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2009.00236.x
Keywords
allergens; early life; immune system; micronutrients; pathogens
Categories
Funding
- NIH NCI [CA 29502, R25 105012]
- NIH NCRR [M01 RR 6020, M01RR0004, UL1 RR024996]
- NIH NCCAM
- ODS [1-P50-AT02779]
- The Children's Cancer and Blood Foundation
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Nutrients exert unique regulatory effects in the perinatal period that mold the developing immune system. The interactions of micronutrients and microbial and environmental antigens condition the post-birth maturation of the immune system, influencing reactions to allergens, fostering tolerance towards the emerging gastrointestinal flora and ingested antigens, and defining patterns of host defense against potential pathogens. The shared molecular structures that are present on microbes or certain plants, but not expressed by human cells, are recognized by neonatal innate immune receptors. Exposure to these activators in the environment through dietary intake in early life can modify the immune response to allergens and prime the adaptive immune response towards pathogens that express the corresponding molecular structures.
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