Journal
TALANTA
Volume 134, Issue -, Pages 712-717Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2014.12.013
Keywords
Magnetic mesoporous nanoparticles; Peroxidase-mimic activity; Glucose; Detection
Categories
Funding
- National Natural Science Foundation of China [21305164]
- State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University [2013019]
- Scientific Research Fund of Hunan Provincial Education Department ( [13C1138]
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In this work, we synthesized a type of magnetic mesoporous silica nanoparticle (denoted as Fe3O4@MSN) with Fe3O4 as the core and mesoporous silica the shell. The superparamagnetic Fe3O4-core provides high peroxidase-mimic activity and makes the artificial enzymatic system easily recyclable. Furthermore, Fe3O4 nanoparticles are encapsulated in MSN shells to hinder the aggregation and keep them stable even under harsh conditions. Meanwhile, small active molecules are allowed to diffuse in and out of the MSN shells. Based on these functional units, the Fe3O4@MSN as robust nanoreactors can catalyze a self-organized cascade reaction, which includes oxidation of glucose by oxygen to yield gluconic acid and H2O2, and the latter further oxidizes 3,3,5,5-tetramethylbenzidine (TMB) to produce a color change. The Fe3O4@MSN, whose catalytic efficiency was not strongly dependent on pH and temperature, was successfully used for the detection of glucose and showed excellent sensitivity with a detection limit of 0.4 x 10(-5) mol/L. Nevertheless, the assay is also highly selective toward the glucose detection. (C) 2014 Elsevier B.V. All rights reserved.
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