Journal
NUTRITION REVIEWS
Volume 66, Issue 7, Pages 415-421Publisher
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2008.00051.x
Keywords
animal studies; body weight; conjugated linoleic acid; fat loss; human clinical trials; metabolism
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Conjugated linoleic acids (CLA) ore positional and geometric isomers of linoleic acid. In animals, CLA consumption reduces body fat but results in humans are less conclusive. This review of the literature on CLA and loss of body fat or body weight in humans was conducted to explore the reasons for the discrepancy between animal and clinical trials. It indicates that the incongruity between human and animal data is largely related to methodological differences in the experimental design, including age and gender and, to a lesser extent, to CLA dose and isomers. The relatively unknown metabolic fate of CLA in humans may also be a contributing factor that helps explain the lack of consistency for CLA efficacy across studies. (c) 2008 International Life Sciences Institute.
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