Journal
NUTRITION REVIEWS
Volume 66, Issue 10, Pages S139-S146Publisher
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2008.00099.x
Keywords
adipocyte; calcitriol; calcium; energy metabolism; uncoupling protein 2
Categories
Ask authors/readers for more resources
Calcitriol, a calcitrophic hormone that can be suppressed by high dietary calcium, favors fatty acid synthesis and inhibits lipolysis via non-genomic modulation of Ca2+ influx. Calcitriol also suppresses UCP2 expression via the nVDR and thereby increases energy efficiency. Calcitriol exerts a dose-dependent impact on adipocyte apoptosis and regulates adipose tissue fat depot location and expansion by promoting glucocorticoid production and release. Recent data also demonstrate a pivotal role of calcitriol in the modulation of cytokines, with potential roles in energy metabolism in adipocytes, macrophages, and skeletal muscle. (C) 2008 International Life Sciences Institute.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available