Journal
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume 24, Issue 9, Pages 956-962Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2014.03.009
Keywords
Sedentary time; Type 2 diabetes; Breaks in sedentary time; Inflammation
Funding
- National Institute for Health Research (NIHR) Bristol Nutrition Biomedical Research Unit at University Hospitals Bristol NHS Foundation Trust
- University of Bristol
- National Institutes of Health Research (NIHR) [PB-PG-0610-22352] Funding Source: National Institutes of Health Research (NIHR)
- National Institute for Health Research [PB-PG-0610-22352] Funding Source: researchfish
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Background and aims: We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. Methods and results: We studied 285 adults (184 men, 101 women, mean age 59.0 +/- 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 + 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men. Conclusions: Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes. (C) 2014 Elsevier B. V. All rights reserved.
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