SLC30A8 polymorphism and type 2 diabetes risk: Evidence from 27 study groups

Background and aims: Intense research has been performed to identify the genetic risk factors in type 2 diabetes, and a single nucleotide polymorphism (SNP) in SLC30A8 (rs13266634) was reported to be associated with type 2 diabetes mellitus. However, published data on the association between SLC30A8 polymorphism and the risk of type 2 diabetes were inconsistent. Therefore, we conducted this meta-analysis to derive a more precise estimation of the relationship. Methods and results: We searched PubMed through October 2009 to identify all relevant papers. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted under an additive genetic model. In the current meta-analysis, we identified a total of 27 groups including 42,609 cases and 69,564 controls. In analyses of the case-control studies by ethnicity, the results indicated that SLC30A8 polymorphism was related to elevate risks of type 2 diabetes both in Europeans (OR = 1.15, 95% CI 1.11-1.18, P < 0.001) and Asians (OR = 1.15, 95% CI 1.11-1.19, P < 0.001). Next, we separated hospital-based case-control studies from population-based case-control studies, however, there was no apparent difference between population-based case-control study groups (OR = 1.15, 95% CI 1.12-1.17, P < 0.001) and hospital-based case-control study groups (OR = 1.16, 95% CI 1.07-1.25, P < 0.001). Conclusion: Our present meta-analysis provided evidence that SLC30A8 (rs13266634) C allele carriers could elevate the risk of type 2 diabetes, especially in Europeans and Asians. (C) 2009 Elsevier B.V. All rights reserved.