Journal
NUTRITION IN CLINICAL PRACTICE
Volume 23, Issue 3, Pages 275-283Publisher
WILEY
DOI: 10.1177/0884533608318672
Keywords
irritable bowel syndrome; nutrition therapy; visceral afferents
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Funding
- National Institute of Nursing Research [NR01094, P30 NR04001]
- National Institutes of Health
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Irritable bowel syndrome (IBS) is a chronic functional GI disorder characterized by abdominal pain associated with alterations in defecation or stool frequency and consistency. In Western industrialized countries, women seek health care services for their symptoms more frequently than men. The cause of IBS is likely multifactorial involving altered motility, visceral hypersensitivity, and dysregulation of the autonomic nervous system. Many patients note that their symptoms are exacerbated by diet and stress, and women frequently report menstrual cycle fluctuations in symptoms. Current approaches to IBS management include behavioral management therapies such as dietary intake changes and stress reduction cognitive restructuring. Drug therapies are targeted at altering pain sensitivity, motility, and secretion. This review provides an overview of the pathogenesis of IBS, factors that contribute to gender differences, and current therapeutic approaches for symptom management. (Nutr Clin Pract. 2008;23:275-283)
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