Journal
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Volume 66, Issue 4, Pages 566-575Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/01635581.2014.894097
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Funding
- NIH National Center for Complementary and Alternative Medicine [1R21AT004024-01]
- Pathology Resource Network is a Roswell Park Cancer Center Support Grant shared resource - NIH National Cancer Institute [P30CA016056-32]
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Use of complementary approaches is common among breast cancer survivors. Potential interactions between aromatase inhibitors (AI) and high phytoestrogen foods, such as flaxseed (FS), are not often described. We conducted a pilot 2 x 2 factorial, randomized intervention study between tumor biopsy and resection, in 24 postmenopausal women with estrogen receptor positive (ER+) breast cancer, to assess the effects of FS and anastrozole, and possible interactions between them, on serum steroid hormone and tumor-related characteristics associated with long-term survival (Roswell Park Cancer Institute, 2007-2010). The effect of each treatment vs. placebo on outcomes was determined by linear regression adjusting for pretreatment measure, stage, and grade. Although not statistically significant, mean ER expression was approximately 40% lower from pre- to postintervention in the FS + AI group only. We observed a statistically significant negative association ( +/- SE -0.3 +/- 0.1; P = 0.03) for androstenedione in the FS + AI group vs. placebo and for DHEA with AI treatment ( +/- SE -1.6 +/- 0.6; P = 0.009). Enterolactone excretion was much lower in the FS + AI group compared to the FS group. Our results do not support strong effects of FS on AI activity for selected breast tumor characteristics or serum steroid hormone levels but suggest AI therapy might reduce the production of circulating mammalian lignans from FS.
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