Journal
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Volume 64, Issue 2, Pages 307-314Publisher
LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS
DOI: 10.1080/01635581.2012.648819
Keywords
-
Categories
Funding
- National Cancer Institute [R01 CA 80843, P30 CA 71789]
- National Center for Research Resources [S10 RR 020890]
- [R25 CA 90956]
Ask authors/readers for more resources
One of the hypothesized protective mechanisms of soy against breast cancer involves changes in estrogen metabolism to 2-hydroxy (OH) and 16 alpha-OH estrogens. The current analysis examined the effect of soy foods on the 2:16 alpha-OH E-1 ratio among premenopausal women during a randomized, crossover intervention study; women were stratified by equol producer status, a characteristic thought to enhance the protective effects of soy isoflavones. The study consisted of a high-soy diet with 2 soy food servings/day and a low-soy diet with <3 servings of soy/wk for 6 mu each; estrogen metabolites were measured in 3 overnight urines (baseline and at the end of the low- and high-soy diet) using gas chromatography mass spectrometry for the 82 women who completed the study. Urinary isoflavonoids were assessed by liquid chromatography mass spectrometry. When applying mixed models, the 2:16 alpha-OH E-1 ratio increased (P = 0.05) because of a nonsignificant decrease in 16 alpha-OH E-1 (P = 0.21) at the end of the high-soy diet. Similar nonsignificant increases in the 2:16 alpha-OH E-1 ratio were observed in equol producers (P = 0.13) and nonproducers (P = 0.23). These findings suggest a beneficial influence of soy foods on estrogen metabolism regardless of equol producer status.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available