Journal
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Volume 63, Issue 8, Pages 1348-1360Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/01635581.2011.608480
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Funding
- Polish Ministry of Science and Higher Education [N312 028 32/1893]
- Institute of Medical Biology of PAS
- Norwegian Financial Mechanism [PL0107]
- EEA Financial Mechanism
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Plant proanthocyanidins, including procyanidins, display various biological activities. Here we report an inhibition of human colon cancer Caco-2 cell growth by the extract from Japanese quince fruit and the procyanidin-rich fractions of the extract. We observed that the amount of apoptotic Caco-2 cells increased by 52.1% vs. control after 72-h incubation with 50 mu g extract/mL, as assessed by flow cytometry and image cytometry. Under the same experimental conditions the corresponding values for human colon cancer HT-29 cells and for rat normal intestinal IEC-6 cells were 5.0% and 8.1%, respectively. The extract fractions enriched with higher oligomers exhibited the highest proapoptotic activity. In conclusion, the Japanese quince procyanidins exhibited proapoptotic activity in Caco-2 cells within a submilimolar concentration range.
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