Journal
NUTRITION
Volume 30, Issue 10, Pages 1210-1212Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2014.02.029
Keywords
Pomegranate; Clostridum difficile; Pomegranate extract; Susceptibility; Minimum inhibitory concentration; MIC
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Objective: To determine the possible utility of pomegranate extract in the management or prevention of Clostridium difficile infections or colonization. Method: The activity of pomegranate was tested against 29 clinical C difficile isolates using the Clinical and Laboratory Standards Institute-approved agar dilution technique. Total phenolics content of the pomegranate extract was determined by Folin-Ciocalteau calorimetric method and final concentrations of 625 to 400 mu g/mL gallic acid equivalent were achieved in the agar. Results: All strains had MICs at 12.5 to 25 mg/mL gallic acid equivalent range. Our results suggest antimicrobial in vitro activity for pomegranate extract against toxigenic C difficile. Conclusion: Pomegranate extract may be a useful contributor to the management and prevention of C. difficile disease or colonization. (C) 2014 Elsevier Inc. All rights reserved.
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