Journal
NUTRITION
Volume 30, Issue 7-8, Pages 794-799Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2013.12.006
Keywords
Kidney; Glomerular filtration rate; Vegetable protein; Animal protein; Macronutrients
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Funding
- National Heart, Lung, and Blood Institute (NHLBI) [HHSN268201200036 C, HHSN268200800007 C, N01 HC55222, N01 HC85079, N01 HC85080, N01 HC85081, N01 HC85082, N01 HC85083, N01 HC85086, HL080295]
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Aging (NIA) [AG023629, 4 R00 AG035002]
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Objective: With aging, kidney function declines, as evidenced by reduced glomerular filtration rate. It is controversial whether or not high protein intake accelerates this decline. The aim of this study was to determine whether high protein intake was associated with declines in kidney function among older patients. Methods: We examined whether dietary protein is associated with change in kidney function (mean follow-up 6.4 y [SD = 1.4, range = 2.5-7.9] in the Cardiovascular Health Study (N = 3623). We estimated protein intake using a food frequency questionnaire and estimated glomerular filtration rate from cystatin C. Associations between protein intake and kidney function were determined by linear and logistic regression models. Results: Average protein intake was 19% of energy intake (SD = 5%). Twenty-seven percent (n = 963) of study participants had rapid decline in kidney function, as defined by (Delta eGFR(cysC) > 3 ml.min.1.73 m(2)). Protein intake (characterized as g/d and % energy/d), was not associated with change in estimated glomerular filtration rate (P > 0.05 for all comparisons). There were also no significant associations when protein intake was separated by source (animal and vegetable). Conclusion: These data suggest that higher protein intake does not have a major effect on kidney function decline among elderly men and women. (C) 2014 Elsevier Inc. All rights reserved.
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