Journal
NUTRITION
Volume 27, Issue 5, Pages 530-533Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2010.05.016
Keywords
Ascorbic acid; Malnutrition; Nutritional supplements; Scurvy; Vitamin D
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Funding
- Lotte and John Hecht Memorial Foundation
- McGill University
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Objective: Hypovitaminosis C and D are highly prevalent in acutely hospitalized patients, but the clinical significance of these biochemical abnormalities is not known. Because deficiencies of vitamin C and D have been linked to psychologic abnormalities, vitamin C or D provision could improve the mood state of acutely hospitalized patients. Methods: Double-blind clinical trial of the effect of vitamin C (500 mg twice daily) or vitamin D (1000 IU twice daily) on mood, as assessed with a validated instrument, the Profile of Mood States. Results: Vitamin C therapy increased plasma (P < 0.0001) and mononuclear leukocyte (P = 0.014) vitamin C concentrations and was associated with a 34% reduction in mood disturbance (P = 0.013). Vitamin D therapy increased plasma 25-hydroxyvitamin D concentrations (P = 0.0004), but had no significant effect On mood. Conclusions: Treatment of hypovitaminosis C improves the mood state of acutely hospitalized patients. (C) 2011 Elsevier Inc. All rights reserved.
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