Journal
NUTRITION
Volume 24, Issue 5, Pages 401-406Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2007.12.017
Keywords
glycemic index; glycemic load; high-sensitivity C-reactive protein; diet; carbohydrate; cardiovascular diseases
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Funding
- NHLBI NIH HHS [R21 HL074895, R21 HL074895-02, R21 HL076796-01, R01-HL52745, R21 HL076796-02, R21 HL076796, 1 R21 HL074895-01] Funding Source: Medline
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Objective: This study examined the relation between quality of dietary carbohydrate intake, as measured by glycemic index (GI) and glycemic load (GL), and serum high-sensitivity C-reactive protein (hs-CRP) levels.. Methods: During a 1-y observational study, data were collected at baseline and at each quarter thereafter. GI and GL were calculated from multiple 24-h dietary recalls (24HRs), 3 randomly selected 24HRs at every quarter, with up to 15 24HRs per participant. The hs-CRP was measured in blood samples collected at baseline and each of the four quarterly measurement points. Multi- variable linear mixed models were used to examine the cross-sectional and longitudinal associations of GI, GL, and hs-CRP. Results: Among 582 adult men and women with at least two measurements of diet and hs-CRP, average daily GI score (white bread = 100) was 85 and average GL was 198, and average hs-CRP was 1.84 mg/L. Overall, there was no association between GI or GL and hs-CRP. Subgroup analyses revealed an inverse association between GL and hs-CRP among obese individuals (body mass index; >= 30 kg/m(2)). Conclusion: Quality of dietary carbohydrates does not appear to be associated with serum hs-CRP levels. Among obese individuals, higher dietary GL appears to be related to lower hs-CRP levels. Due to the limited number of studies on this topic and their conflicting results, further investigation is warranted. 0 2008 Elsevier Inc. All rights reserved.
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