Journal
SYNTHETIC COMMUNICATIONS
Volume 45, Issue 22, Pages 2608-2626Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2015.1099675
Keywords
Alloxan; azide; catalyst; clay-copper(II); synthesis; triazoles
Categories
Funding
- Defence Research and Development Organization (DRDO), New Delhi [ERIP/ER/1103024/M/01/1476]
Ask authors/readers for more resources
A novel series of alloxan-derived 1,4-disubstituted 1,2,3-triazoles was synthesized in excellent yields under catalytic conditions using a click reaction strategy through 1,3-dipolar cycloaddition. Their structures have been ascertained on the basis of spectroanalytical and elemental analysis data. Synthesis of hybrid compounds with varying substitutions in the triazole ring was achieved by reaction between alloxan-derived terminal alkyne and a pertinent azide derivative in the presence of clay-Cu(II) as the catalyst in methanolic medium. Also, comparative evaluation of various catalytic systems [viz., CuI, CuSO4, CuI-zeolite, K10Ti, and clay-Cu(II)] was investigated. Of these catalytic systems, clay-Cu(II) was observed to be the best. The catalyst was recyclable for several runs without showing significant loss in its activity. The good selectivity, cost-efficiency, short reaction time, milder reaction conditions, and simple workup procedure are the added salient features of this synthetic protocol.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available