Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 33, Issue 7, Pages 455-465Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2014.885045
Keywords
Phosphorylases; gene regulation; mechanism of action studies
Categories
Funding
- National Natural Science Foundation of China [81301599]
- Sichuan Province Science and Technology Support Project [2011SZZ012]
- North Sichuan Medical College Program [KFJJ10-06]
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Glut9 is highly expressed in the human kidney proximal convoluted tubular and plays a crucial role in the regulation of plasma urate levels. The gene effects were stronger among women. Our results show that 17--estradiol (E2) through ER (estrogen receptor) downregulates Glut9 protein expression on human renal tubular epithelial cell line (HK2). Intriguingly, E2 does not affect the expression of Glut9 mRNA. ER is linked to PTEN, the PTEN gene negatively regulates the PI3K/AKT pathway, and the PI3K/AKT pathway inhibition may lead to autophagy. Further study indicates that ER may affect the expression of Glut9 though autophagy.
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