Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 31, Issue 1-3, Pages 130-146Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2011.644369
Keywords
Chromeno[2,3-b]quinoline; 1,10 phenanthroline; dibenzo[b,g] [1,8] naphthyridine; DNA binding; DNA cleavage
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Four new Co(III) complexes, namely [Co(ca)(3)](PF6)(3), [Co(phen)(2)(cq)](PF6)(3), [Co(bnp)(3)] (PF6)(3), and [Co(phen)(2)(bnp)](PF6)(3) (where cq = chromeno[2,3-b]quinoline, phen = 1,10-phenanthroline and bnp = dibenzo[b,g][1,8]naphthyridine), were synthesized and structurally characterized. Spectroscopic data suggested an octahedral geometry for all the complexes. Binding studies of these complexes with double-stranded (dc)DNA were analyzed by absorption spectra, viscosity, and thermal denaturation studies. The mulls revealed that the metal complex intercalates into the DNA base stack as intercalator. The oxidative cleavage activities of the complexes were studied with supercoiled pUC19 DNA using gel electrophoresis and the results show that the complexes have potent nuclease activity.
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