Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 29, Issue 3, Pages 155-167Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257771003708462
Keywords
Dendrimers; fluorescence; DNA; supramolecular interactions; electrophoresis; circular dichroism
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Funding
- French-Polish LEA (MOMACHEM)
- ITAV programme
- ANR PCV BIODENDRIDOT
- CNRS
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The synthesis of a water-soluble phosphorus-containing dendrimer possessing a fluorophore (maleimide-type) linked to the core is described. This dendrimer is found brightly fluorescent in CH2Cl2, but poorly fluorescent in water. The cytotoxicity of this compound is relatively low towards HeLa and A549 cells, and less toxic after 48 hours than after 24 hours. Association of this dendrimer with plasmid DNA (BACE-GFP) analyzed with circular dichroism (CD) indicates a possible disturbing of the helical B-type structure of DNA. The strength of this association (a odendriplexo) with BACE-GFP (also with HygEGFP) was measured by electrophoresis.
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