Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 28, Issue 3, Pages 238-259Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770902865415
Keywords
Nucleoside; nucleotide; sirtuin; inhibition
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Funding
- Medical Research Council [GR0100461] Funding Source: Medline
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The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.
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