Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 28, Issue 10, Pages 953-968Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770903307060
Keywords
Ru(II)complexes; polypyridyl ligand; calf-thymus DNA; photocleavage; intercalative mode; toxicology
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Four Ru(II) polypyridyl complexes, [Ru(bpy)(2)(7-NO2-dppz)](2+), [Ru(bpy)(2)(7-CH3-dppz)](2+), [Ru(phen)(2)(7-NO2-dppz)](2+), and [Ru(phen)(2)(7-CH3-dppz)](2+) (bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline), (7-Nitro-dppz = 7-Nitro dipyrido[3,2-a:2'-3'-c]phenazine, 7-CH3-dppz = 7-Methyl dipyrido[3,2-a:2'-3'-c]phenazine), have been synthesized and characterized by IR, UV, elemental analysis, H-1 NMR, C-13-NMR, and mass spectroscopy. The DNA-binding properties of the four complexes were investigated by spectroscopic and viscosity measurements. The results suggest that all four complexes bind to DNA via air intercalative mode. Under irradiation at 365 nm, all four complexes were found to promote the photocleavage of plasmid pBR 322 DNA. Toxicological effects of the selected complexes were performed on industrially important yeasts (eukaryotic microorganisms).
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