Advances in Transition-Metal-Catalyzed Direct sp3-Carbon-Hydrogen Bond Functionalization

Transition-metal-catalyzed direct carbon-hydrogen bond functionalization has made significant advances in the field of carbon-hydrogen bond activation over the past decades. This methodology has the potential to be used in many different areas of chemistry; for example, it can provide an opportunity for the synthesis of various kinds of complex compounds. This account mainly focuses on recent advances in transition-metal-catalyzed direct sp(3)-carbon-hydrogen bond functionalization to form carbon-carbon bonds. 1 Introduction 2 Carbon-Carbon Bond Formation via Direct sp(3)-Carbon-Hydrogen Bond Functionalization 2.1 Coupling of sp(3)-Carbon-Hydrogen and sp-Carbon-Hydrogen Bonds 2.2 Coupling of sp(3)-Carbon-Hydrogen and sp(2)-Carbon-Hydrogen Bonds 2.3 Coupling of sp(3)-Carbon-Hydrogen and sp(3)-Carbon-Hydrogen Bonds 2.4 Coupling of sp(3)-Carbon-Hydrogen and C-X Bonds 3 Conclusion