Journal
NUCLEIC ACIDS RESEARCH
Volume 42, Issue W1, Pages W285-W289Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gku397
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Funding
- National Cancer Institute, National Institutes of Health (NIH) [HHSN261200800001E]
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
- Scientific and Technological Research Council of Turkey (TUBITAK) [113E164]
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The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model.
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