4.4 Article

Asymmetric Conjugate Addition of Ketones to Maleimides Using Diaminomethyleneindenedione Organocatalyst

Journal

SYNLETT
Volume 26, Issue 9, Pages 1248-1252

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1380382

Keywords

organocatalyst; maleimide; conjugate addition; asymmetric reaction; ketone

Funding

  1. Grants-in-Aid for Scientific Research [15K18838] Funding Source: KAKEN

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A novel diaminomethyleneindenedione (DMI) organocatalyst efficiently promotes the asymmetric conjugate addition of a ketone to a maleimide to afford the corresponding addition product in a high yield with up to 99% enantiomeric excess.

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