Journal
SYNLETT
Volume 26, Issue 20, Pages 2731-2738Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1381059
Keywords
biomimetic catalysis; aerobic oxidation; phenols; dearomatization; enzymes; C-H functionalization; copper
Categories
Funding
- Natural Sciences and Engineering Council of Canada
- Fonds de Recherche du Quebec-Nature et Technologies
- McGill University-Canadian Institutes of Health Drug Development Trainee Program
- McGill University
Ask authors/readers for more resources
The importance of aromatic carbon-heteroatom bonds to the function of natural products, electronic materials, and pharmaceutically active compounds motivates considerable effort to improve the efficiency of constructing these bonds. Melanogenesis, which is a ubiquitous process by which organisms produce pigments, generates functional materials with high heteroatom content from simple phenolic precursors at the sole expense of reducing molecular oxygen to water. This article outlines our efforts towards the development of a tyrosinase mimic for the aerobic oxygenation of phenols that were inspired by melanogenesis, and highlights its potential to functionalize multiple aromatic C-H bonds in a single operation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available