Journal
NUCLEIC ACIDS RESEARCH
Volume 43, Issue D1, Pages D549-D557Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gku1137
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Funding
- Chinese National Natural Science Foundations [31200626, 31460233]
- Programme for Changjiang Scholars and the Innovative Research Teams at the University [PCSIRT-1227]
- Initial Fund for the Key Laboratory of Guizhou Province [2011-4005]
- Guizhou Lianhe Foundation [LKS(2012)22]
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The Central Carbon Metabolic Flux Database (CeCaFDB, available at http://www.cecafdb.org) is a manually curated, multipurpose and open-access database for the documentation, visualization and comparative analysis of the quantitative flux results of central carbon metabolism among microbes and animal cells. It encompasses records for more than 500 flux distributions among 36 organisms and includes information regarding the genotype, culture medium, growth conditions and other specific information gathered from hundreds of journal articles. In addition to its comprehensive literature-derived data, the CeCaFDB supports a common text search function among the data and interactive visualization of the curated flux distributions with compartmentation information based on the Cytoscape Web API, which facilitates data interpretation. The CeCaFDB offers four modules to calculate a similarity score or to perform an alignment between the flux distributions. One of the modules was built using an inter programming algorithm for flux distribution alignment that was specifically designed for this study. Based on these modules, the CeCaFDB also supports an extensive flux distribution comparison function among the curated data. The CeCaFDB is strenuously designed to address the broad demands of biochemists, metabolic engineers, systems biologists and members of the -omics community.
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