Journal
NUCLEIC ACIDS RESEARCH
Volume 42, Issue W1, Pages W271-W276Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gku339
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Funding
- Human Frontier Science Program [RGP0039/2008]
- Ministerio de Economia y Competitividad [BFU2013-44306P]
- Comunidad de Madrid [CAM-S2010/BMD]
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Normal mode analysis (NMA) in internal (dihedral) coordinates naturally reproduces the collective functional motions of biological macromolecules. iMODS facilitates the exploration of such modes and generates feasible transition pathways between two homologous structures, even with large macromolecules. The distinctive internal coordinate formulation improves the efficiency of NMA and extends its applicability while implicitly maintaining stereochemistry. Vibrational analysis, motion animations and morphing trajectories can be easily carried out at different resolution scales almost interactively. The server is versatile; non-specialists can rapidly characterize potential conformational changes, whereas advanced users can customize the model resolution with multiple coarse-grained atomic representations and elastic network potentials. iMODS supports advanced visualization capabilities for illustrating collective motions, including an improved affine-model-based arrow representation of domain dynamics. The generated all-heavy-atoms conformations can be used to introduce flexibility for more advanced modeling or sampling strategies.
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