Journal
NUCLEIC ACIDS RESEARCH
Volume 42, Issue D1, Pages D142-D147Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkt997
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Funding
- Novo Nordisk Foundation
- Lundbeck Foundation
- European Research Council under the EU/ERC [204135]
- Canadian Institutes for Health Research
- National Sciences and Engineering Research Council of Canada
- National Institute of General Medical Sciences [R01GM084875]
- Michael Smith Foundation for Health Research
- GenomeCanada
- Genome British Columbia
- Rhones-Alpes region CMIRA fellowship
- CNRS
- EU [HEALTH-F4-2010-242048]
- Medical Research Council UK
- Department of Informatics, University of Bergen
- Lundbeck foundation for the AS lab
- Medical Research Council (UK) for the B.L. lab
- National Institute of General Medical Sciences for the W.W.W. lab [R01GM084875]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM084875] Funding Source: NIH RePORTER
- MRC [MC_UP_1102/1] Funding Source: UKRI
- Medical Research Council [MC_UP_1102/1] Funding Source: researchfish
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JASPAR (http://jaspar.genereg.net) is the largest open-access database of matrix-based nucleotide profiles describing the binding preference of transcription factors from multiple species. The fifth major release greatly expands the heart of JASPAR-the JASPAR CORE subcollection, which contains curated, non-redundant profiles-with 135 new curated profiles (74 in vertebrates, 8 in Drosophila melanogaster, 10 in Caenorhabditis elegans and 43 in Arabidopsis thaliana; a 30% increase in total) and 43 older updated profiles (36 in vertebrates, 3 in D. melanogaster and 4 in A. thaliana; a 9% update in total). The new and updated profiles are mainly derived from published chromatin immunoprecipitation-seq experimental datasets. In addition, the web interface has been enhanced with advanced capabilities in browsing, searching and subsetting. Finally, the new JASPAR release is accompanied by a new BioPython package, a new R tool package and a new R/Bioconductor data package to facilitate access for both manual and automated methods.
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