4.4 Article

3,5-Disubstituted 2-Aminopyridines via Nickel-Catalyzed Cyclo-addition of Terminal Alkynes and Cyanamides

Journal

SYNLETT
Volume 26, Issue 3, Pages 307-312

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1379500

Keywords

nickel; catalyst; cycloaddition; 2aminopyridnes; regiose lectivity

Funding

  1. NIH [GM076125]
  2. NSF [0911017]
  3. Division Of Chemistry
  4. Direct For Mathematical & Physical Scien [0911017] Funding Source: National Science Foundation

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The regioselectivity of the Ni/SIPr-catalyzed cyc addition terminal alkynes and cyanamides was explored. In general, 3,5-disubstituted 2-aminopyridines were formed as the major product.

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