4.4 Article

Oxidative Cleavage of C2-C3 Bond in Isatin Using (Diacetoxyiodo)benzene: A Facile Synthesis of Carbamates of Alkyl Anthranilates

Journal

SYNLETT
Volume 27, Issue 5, Pages 763-768

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1560990

Keywords

Hofmann rearrangement; phthalimide; isatin; hypervalent iodine; 1; 2-dicarbonyl cleavage

Funding

  1. Department of Science and Technology, New Delhi, India [SR/S1/OC-72/2009]

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On reaction with (diacetoxyiodo)benzene, isatin and N-acetyl isatin undergo the oxidative C2-C3 bond cleavage to form carbamates of alkyl anthranilates and alkyl 2-acetamidobenzoate, respectively.

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