Journal
NUCLEIC ACIDS RESEARCH
Volume 42, Issue D1, Pages D802-D809Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkt977
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Categories
Funding
- National Institutes of Health (NIH) [1 U54 HG006370-01]
- EMBL-EBI Core Funding
- Wellcome Trust Core Funding
- NIH [1 U54 HG006370-01]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U54HG006370] Funding Source: NIH RePORTER
- MRC [MC_U142684171, MC_U142684172] Funding Source: UKRI
- Medical Research Council [MC_U142684172, MC_U142684171] Funding Source: researchfish
Ask authors/readers for more resources
The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated 'data wranglers' work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease. As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases.
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