Journal
NUCLEIC ACIDS RESEARCH
Volume 42, Issue D1, Pages D789-D793Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkt1063
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Categories
Funding
- US National Human Genome Research Institute [U41-HG002223]
- British Medical Research Council [G070119]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [P41HG002223, U41HG002223] Funding Source: NIH RePORTER
- Medical Research Council [MR/L001020/1] Funding Source: researchfish
- MRC [MR/L001020/1] Funding Source: UKRI
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WormBase (http://www.wormbase.org/) is a highly curated resource dedicated to supporting research using the model organism Caenorhabditis elegans. With an electronic history predating the World Wide Web, WormBase contains information ranging from the sequence and phenotype of individual alleles to genome-wide studies generated using next-generation sequencing technologies. In recent years, we have expanded the contents to include data on additional nematodes of agricultural and medical significance, bringing the knowledge of C. elegans to bear on these systems and providing support for underserved research communities. Manual curation of the primary literature remains a central focus of the WormBase project, providing users with reliable, up-to-date and highly crosslinked information. In this update, we describe efforts to organize the original atomized and highly contextualized curated data into integrated syntheses of discrete biological topics. Next, we discuss our experiences coping with the vast increase in available genome sequences made possible through next-generation sequencing platforms. Finally, we describe some of the features and tools of the new WormBase Web site that help users better find and explore data of interest.
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