Journal
SYNLETT
Volume 27, Issue 1, Pages 101-105Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1560578
Keywords
sulfonamides; palladium catalysis; sulfinates; amines; aryl halides
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Funding
- EPSRC
- Engineering and Physical Sciences Research Council [EP/K024205/1, EP/K00803X/1] Funding Source: researchfish
- EPSRC [EP/K024205/1, EP/K00803X/1] Funding Source: UKRI
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Aryl ammonium sulfinates, conveniently prepared from aryl iodides and the sulfur dioxide surrogate DABSO, under the action of a palladium(0) catalyst, are transformed in a one-pot process to a variety of functionalized sulfonamides. The sulfinate to sulfonamide transformation is achieved by simple treatment with an aqueous solution of the relevant amine and sodium hypochlorite (bleach). A broad range of amines, including anilines, and amino acid derivatives, are combined efficiently with a variety of aryl iodides, leading to sulfonamides in high yields.
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