4.8 Article

Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends

Related references

Note: Only part of the references are listed.
Editorial Material Biochemistry & Molecular Biology

FEN Nucleases: Bind, Bend, Fray, Cut

R. Scott Williams et al.

Article Biochemistry & Molecular Biology

Neutralizing Mutations of Carboxylates That Bind Metal 2 in T5 Flap Endonuclease Result in an Enzyme That Still Requires Two Metal Ions

Christopher G. Tomlinson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

Martin Jinek et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

Jeong Ho Chang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Functional regulation of FEN1 nuclease and its link to cancer

Li Zheng et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Biochemistry & Molecular Biology

Substrate recognition and catalysis by flap endonucleases and related enzymes

Christopher G. Tomlinson et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2010)

Article Biochemistry & Molecular Biology

Flap Endonuclease 1 Mechanism Analysis Indicates Flap Base Binding Prior to Threading

Jason W. Gloor et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

Zhigang Guo et al.

NATURE CHEMICAL BIOLOGY (2010)

Article Biochemical Research Methods

A streptavidin variant with slower biotin dissociation and increased mechanostability

Claire E. Chivers et al.

NATURE METHODS (2010)

Article Biochemistry & Molecular Biology

Coordination of dual incision and repair synthesis in human nucleotide excision repair

Lidija Staresincic et al.

EMBO JOURNAL (2009)

Article Biochemistry & Molecular Biology

The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis

L. David Finger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Rapid and efficient DNA strand cross-linking by click chemistry

Petr Kocalka et al.

CHEMBIOCHEM (2008)

Article Biochemistry & Molecular Biology

Three metal ions participate in the reaction catalyzed by T5 flap endonuclease

Karl Syson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Identification of Holliday junction resolvases from humans and yeast

Stephen C. Y. Ip et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease

Ryan Williams et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Structural basis for recruitment of human flap endonuclease 1 to PCNA

S Sakurai et al.

EMBO JOURNAL (2005)

Article Chemistry, Medicinal

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors

LN Tumey et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Biochemistry & Molecular Biology

The Fen1 extrahelical 3′-flap pocket is conserved from archaea to human and regulates DNA substrate specificity

E Friedrich-Heineken et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Biochemistry & Molecular Biology

Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage

E Larsen et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG

M Hohl et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease

MR Tock et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

A conserved tyrosine residue aids ternary complex formation, but not catalysis, in phage T5 flap endonuclease

D Patel et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Vertebrate cells lacking FEN-1 endonuclease are viable but hypersensitive to methylating agents and H2O2

Y Matsuzaki et al.

NUCLEIC ACIDS RESEARCH (2002)

Article Biochemistry & Molecular Biology

Contacts between the 5′ nuclease of DNA polymerase I and its DNA substrate

Y Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)