Journal
NUCLEIC ACIDS RESEARCH
Volume 40, Issue D1, Pages D1230-D1234Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr806
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Funding
- King Abdullah University of Science and Technology (KAUST) [KUK-I1-012-43]
- FIRB Proteomica, Ministery of Health [Onc_Ord 25/07]
- IIT SEED
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The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.
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