Journal
NUCLEIC ACIDS RESEARCH
Volume 40, Issue D1, Pages D862-D865Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr967
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Funding
- Cancer Council New South Wales, Australia [SRP11-01, ICGC 09-01]
- National Health and Medical Research Council, Australia [631701]
- Cancer Institute New South Wales, Australia [ICGC 09-01, 10/CRF/1-01]
- Academy of Finland [125826]
- Avner Nahmani Pancreatic Cancer Foundation
- R. T. Hall Trust
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The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified protein-protein interaction data integrated from six manually curated public databases, and a set of built-in tools for network construction, filtering, analysis and visualization. The second version of PINA enhances its utility for studies of protein interactions at a network level, by including multiple collections of interaction modules identified by different clustering approaches from the whole network of protein interactions ('interactome') for six model organisms. All identified modules are fully annotated by enriched Gene Ontology terms, KEGG pathways, Pfam domains and the chemical and genetic perturbations collection from MSigDB. Moreover, a new tool is provided for module enrichment analysis in addition to simple query function. The interactome data are also available on the web site for further bioinformatics analysis. PINA is freely accessible at http://cbg.garvan.unsw.edu.au/pina/.
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