Journal
SYNLETT
Volume 26, Issue 12, Pages 1725-1731Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1380693
Keywords
thiourea catalysts; trifluoromethyl aldimine; beta-keto esters; Mannich reaction; bifunctional organocatalyst
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Funding
- National Natural Science Foundation of China [21262031]
- Key Laboratory Polymer Materials of Gansu Province (Northwest Normal University)
- Bioactive Product Engineering Research Center for Gansu Distinctive Plants
- State Key Laboratory of Applied Organic Chemistry, Lanzhou University
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An efficient bifunctional thiourea catalyzed asymmetric Mannich reaction with trifluoromethyl aldimine as trifluoromethyl building block was achieved to give the products in good diastereoselectivity and enantioselectivity.
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