Journal
NUCLEIC ACIDS RESEARCH
Volume 39, Issue -, Pages W167-W170Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr490
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Funding
- Clore Foundation
- Israel Science Foundation [1403/09]
- Hermann Minkowski-Minerva Center for Geometry at Tel Aviv University
- Sandler Family Supporting Foundation, National Institutes of Health [R01 GM54762, U54 RR022220, PN2 EY016525, R01 GM083960]
- Hewlett-Packard
- NetApp
- IBM
- Intel
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Advances in electron microscopy (EM) allow for structure determination of large biological assemblies at increasingly higher resolutions. A key step in this process is fitting multiple component structures into an EM-derived density map of their assembly. Here, we describe a web server for this task. The server takes as input a set of protein structures in the PDB format and an EM density map in the MRC format. The output is an ensemble of models ranked by their quality of fit to the density map. The models can be viewed online or downloaded from the website. The service is available at; http://salilab.org/multifit/ and http://bioinfo3d.cs.tau.ac.il/.
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