Journal
NUCLEIC ACIDS RESEARCH
Volume 40, Issue D1, Pages D1041-D1046Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr1142
Keywords
-
Categories
Funding
- State Key Basic Research Program (973) [2011CB910204]
- National Natural Science Foundation of China [81101955]
- Major State Basic Research Development Program [2010CB945501]
- 863 Hi-Tech Program of China [2009AA02Z308]
- National Key Technology R&D Program in the 11th Five Year Plan of China [2008BAI64B01]
- Major State Basic Research Development Program of China [2010CB529200]
Ask authors/readers for more resources
Viral integration plays an important role in the development of malignant diseases. Viruses differ in preferred integration site and flanking sequence. Viral integration sites (VIS) have been found next to oncogenes and common fragile sites. Understanding the typical DNA features near VIS is useful for the identification of potential oncogenes, prediction of malignant disease development and assessing the probability of malignant transformation in gene therapy. Therefore, we have built a database of human disease-related VIS (Dr.VIS, http://www.scbit.org/dbmi/drvis) to collect and maintain human disease-related VIS data, including characteristics of the malignant disease, chromosome region, genomic position and viral-host junction sequence. The current build of Dr.VIS covers about 600 natural VIS of 5 oncogenic viruses representing 11 diseases. Among them, about 200 VIS have viral-host junction sequence.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
